Crispr People

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CRISPR People

CRISPR People Pdf/ePub eBook Author: ,
Editor: MIT Press
ISBN: 0262362732
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CRISPR People by , Summary

What does the birth of babies whose embryos had gone through genome editing mean--for science and for all of us? In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos--as dramatic a development in genetics as the cloning of Dolly the sheep was in 1996. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention.

Editing Humanity

Editing Humanity Pdf/ePub eBook Author: Kevin Davies
Editor: Simon and Schuster
ISBN: 1643133942
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Editing Humanity by Kevin Davies Summary

One of the world's leading experts on genetics unravels one of the most important breakthroughs in modern science and medicine. IIf our genes are, to a great extent, our destiny, then what would happen if mankind could engineer and alter the very essence of our DNA coding? Millions might be spared the devastating effects of hereditary disease or the challenges of disability, whether it was the pain of sickle-cell anemia to the ravages of Huntington’s disease. But this power to “play God” also raises major ethical questions and poses threats for potential misuse. For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change. Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale. Though the birth of the “CRISPR babies” in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.

Altered Inheritance

Altered Inheritance Pdf/ePub eBook Author: Françoise Baylis
Editor: Harvard University Press
ISBN: 0674241967
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Altered Inheritance by Françoise Baylis Summary

With the advent of CRISPR gene-editing technology, designer babies have become a reality. Françoise Baylis insists that scientists alone cannot decide the terms of this new era in human evolution. Members of the public, with diverse interests and perspectives, must have a role in determining our future as a species.

A Crack in Creation

A Crack in Creation Pdf/ePub eBook Author: Jennifer A. Doudna,Samuel H. Sternberg
Editor: Houghton Mifflin Harcourt
ISBN: 0544716965
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A Crack in Creation by Jennifer A. Doudna,Samuel H. Sternberg Summary

BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY Finalist for the Los Angeles Times Book Prize “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas “Required reading for every concerned citizen.” — New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “An invaluable account . . . We owe Doudna several times over.” — Guardian

Human Genome Editing

Human Genome Editing Pdf/ePub eBook Author: National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Editor: National Academies Press
ISBN: 0309452910
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Human Genome Editing by National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations Summary

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

The Mutant Project

The Mutant Project Pdf/ePub eBook Author: Eben Kirksey
Editor: St. Martin\'s Press
ISBN: 1250265363
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The Mutant Project by Eben Kirksey Summary

An anthropologist visits the frontiers of genetics, medicine, and technology to ask: Whose values are guiding gene editing experiments? And what does this new era of scientific inquiry mean for the future of the human species? "That rare kind of scholarship that is also a page-turner." —Britt Wray, author of Rise of the Necrofauna At a conference in Hong Kong in November 2018, Dr. He Jiankui announced that he had created the first genetically modified babies—twin girls named Lulu and Nana—sending shockwaves around the world. A year later, a Chinese court sentenced Dr. He to three years in prison for "illegal medical practice." As scientists elsewhere start to catch up with China’s vast genetic research program, gene editing is fueling an innovation economy that threatens to widen racial and economic inequality. Fundamental questions about science, health, and social justice are at stake: Who gets access to gene editing technologies? As countries loosen regulations around the globe, from the U.S. to Indonesia, can we shape research agendas to promote an ethical and fair society? Eben Kirksey takes us on a groundbreaking journey to meet the key scientists, lobbyists, and entrepreneurs who are bringing cutting-edge genetic engineering tools like CRISPR—created by Nobel Prize-winning biochemists Jennifer Doudna and Emmanuelle Charpentier—to your local clinic. He also ventures beyond the scientific echo chamber, talking to disabled scholars, doctors, hackers, chronically-ill patients, and activists who have alternative visions of a genetically modified future for humanity. The Mutant Project empowers us to ask the right questions, uncover the truth, and navigate this brave new world.

How to Grow a Human

How to Grow a Human Pdf/ePub eBook Author: Philip Ball
Editor: University of Chicago Press
ISBN: 022667617X
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How to Grow a Human by Philip Ball Summary

Two summers ago, scientists removed a tiny piece of flesh from Philip Ball’s arm and turned it into a rudimentary “mini-brain.” The skin cells, removed from his body, did not die but were instead transformed into nerve cells that independently arranged themselves into a dense network and communicated with each other, exchanging the raw signals of thought. This was life—but whose? In his most mind-bending book yet, Ball makes that disconcerting question the focus of a tour through what scientists can now do in cell biology and tissue culture. He shows how these technologies could lead to tailor-made replacement organs for when ours fail, to new medical advances for repairing damage and assisting conception, and to new ways of “growing a human.” For example, it might prove possible to turn skin cells not into neurons but into eggs and sperm, or even to turn oneself into the constituent cells of embryos. Such methods would also create new options for gene editing, with all the attendant moral dilemmas. Ball argues that such advances can therefore never be about “just the science,” because they come already surrounded by a host of social narratives, preconceptions, and prejudices. But beyond even that, these developments raise questions about identity and self, birth and death, and force us to ask how mutable the human body really is—and what forms it might take in years to come.

The Last Book in the Universe

The Last Book in the Universe Pdf/ePub eBook Author: Rodman Philbrick
Editor: Scholastic Inc.
ISBN: 0545303877
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The Last Book in the Universe by Rodman Philbrick Summary

This fast-paced action novel is set in a future where the world has been almost destroyed. Like the award-winning novel Freak the Mighty, this is Philbrick at his very best. It's the story of an epileptic teenager nicknamed Spaz, who begins the heroic fight to bring human intelligence back to the planet. In a world where most people are plugged into brain-drain entertainment systems, Spaz is the rare human being who can see life as it really is. When he meets an old man called Ryter, he begins to learn about Earth and its past. With Ryter as his companion, Spaz sets off an unlikely quest to save his dying sister -- and in the process, perhaps the world.

Klara and the Sun

Klara and the Sun Pdf/ePub eBook Author: Kazuo Ishiguro
Editor: Knopf Canada
ISBN: 0735281254
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Klara and the Sun by Kazuo Ishiguro Summary

The magnificent new novel from Nobel laureate Kazuo Ishiguro--author of Never Let Me Go and the Booker Prize-winning The Remains of the Day. “The Sun always has ways to reach us.” From her place in the store, Klara, an Artificial Friend with outstanding observational qualities, watches carefully the behaviour of those who come in to browse, and of those who pass in the street outside. She remains hopeful a customer will soon choose her, but when the possibility emerges that her circumstances may change forever, Klara is warned not to invest too much in the promises of humans. In Klara and the Sun, Kazuo Ishiguro looks at our rapidly changing modern world through the eyes of an unforgettable narrator to explore a fundamental question: what does it mean to love?

The Human Gene Editing Debate

The Human Gene Editing Debate Pdf/ePub eBook Author: John H. Evans
Editor: Oxford University Press
ISBN: 019751958X
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The Human Gene Editing Debate by John H. Evans Summary

In 2018 the first genetically modified babies were reportedly born in China, made possible by the invention of CRISPR technology in 2012. This controversial advancement overturned the pre-existing moral consensus, which had held for over fifty years before: while gene editing an adult person was morally acceptable, modifying babies, and thus subsequent generations, crossed a significant moral line. If this line is passed over, scientists will be left without an agreed-upon ethical limit. What do we do now? John H. Evans here provides a meta-level guide to how these debates move forward and their significance to society. He explains how the bioethical debate has long been characterized as a slippery slope, with consensually ethical use at the top, nightmarish dystopia at the bottom, and specific agreed-upon limits in between, which draw the lines between the ethical and the unethical. Evans frames his analysis around these limits, or barriers. Historically they have existed to guide scientists and to prevent the debate from slipping down the metaphorical slope into unacceptable eugenicist possibilities, such as in Aldous Huxley's novel Brave New World or the movie Gattaca. Evans examines the history of how barriers were placed, then fell, then replaced by new ones, and discusses how these insights inform where the debate may head. He evaluates other proposed barriers relevant to where we are now, projects that most of the barriers suggested by scientists and bioethicists will not hold, and cautiously identifies a few that could serve as the moral boundary for the next generation. At a critical time in this new era of intervention in the human genome, The Human Gene Editing Debate provides a necessary, comprehensive analysis of the conversation's direction, past, present, and future.

The Alchemy of Us

The Alchemy of Us Pdf/ePub eBook Author: Ainissa Ramirez
Editor: MIT Press
ISBN: 0262358085
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The Alchemy of Us by Ainissa Ramirez Summary

In the bestselling tradition of Stuff Matters and The Disappearing Spoon: a clever and engaging look at materials, the innovations they made possible, and how these technologies changed us. In The Alchemy of Us, scientist and science writer Ainissa Ramirez examines eight inventions—clocks, steel rails, copper communication cables, photographic film, light bulbs, hard disks, scientific labware, and silicon chips—and reveals how they shaped the human experience. Ramirez tells the stories of the woman who sold time, the inventor who inspired Edison, and the hotheaded undertaker whose invention pointed the way to the computer. She describes, among other things, how our pursuit of precision in timepieces changed how we sleep; how the railroad helped commercialize Christmas; how the necessary brevity of the telegram influenced Hemingway's writing style; and how a young chemist exposed the use of Polaroid's cameras to create passbooks to track black citizens in apartheid South Africa. These fascinating and inspiring stories offer new perspectives on our relationships with technologies. Ramirez shows not only how materials were shaped by inventors but also how those materials shaped culture, chronicling each invention and its consequences—intended and unintended. Filling in the gaps left by other books about technology, Ramirez showcases little-known inventors—particularly people of color and women—who had a significant impact but whose accomplishments have been hidden by mythmaking, bias, and convention. Doing so, she shows us the power of telling inclusive stories about technology. She also shows that innovation is universal—whether it's splicing beats with two turntables and a microphone or splicing genes with two test tubes and CRISPR.

Howtobuildadragonordietrying:asatiricallookatcutting-edgescience

Howtobuildadragonordietrying:asatiricallookatcutting-edgescience Pdf/ePub eBook Author: Knoepfler Paul,Knoepfler Julie
Editor: World Scientific
ISBN: 9813274484
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Howtobuildadragonordietrying:asatiricallookatcutting-edgescience by Knoepfler Paul,Knoepfler Julie Summary

What if you could have your own real dragon? While that might seem like just a fantasy, today cutting-edge science has brought us to the point where it might really be possible. This book looks into the possibilities of making living, fire-breathing dragons. The world has been fascinated with dragons for thousands of years. Fictional dragons still have a firm place in pop culture, such as Smaug from The Hobbit as well as the dragons in Game of Thrones and in the How to Train Your Dragon movies. This new book discusses using powerful technologies such as CRISPR gene editing, stem cells, and bioengineering to make real dragons. It also goes through what useful information we can learn from animals such as Pteranodons and amazing present-day creatures in our quest to build actual dragons. The book goes on to discuss the possibility of building other mythical creatures such as unicorns and mermaids. Overall, How to Build A Dragon is also meant as a satirical look at cutting-edge science, and it pokes fun at science hype. Anyone who is interested in dragons or cutting-edge science will enjoy this book! It is written in a humorous, approachable way making science fun and easy to understand, including for young adults.The author is well-known scientist Paul Knoepfler who is familiar to the public for his science, his blog The Niche, and his frequent contributions to lay stories on new science concepts such as stem cells and CRISPR. He also is known for his TED talk on designer babies with more than 1.3 million views, and his two books — . The co-author, his daughter Julie Knoepfler, is a high school student interested in science and writing. She has her own blog on literary and film analysis, and enjoys taking a humorous look at culture through writing.

Genome Engineering via CRISPR-Cas9 System

Genome Engineering via CRISPR-Cas9 System Pdf/ePub eBook Author: Vijai Singh,Pawan K. Dhar
Editor: Academic Press
ISBN: 0128181419
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Genome Engineering via CRISPR-Cas9 System by Vijai Singh,Pawan K. Dhar Summary

Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields. Provides basic understanding and a clear picture on how to design, use and implement the CRISPR-Cas9 system in different organisms Explains how to create an animal model for disease research and screening purposes using CRISPR Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, neurology, cancer, industry, and many more

Jurassic Park

Jurassic Park Pdf/ePub eBook Author: Michael Crichton
Editor: Ballantine Books
ISBN: 0307763056
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Jurassic Park by Michael Crichton Summary

#1 NEW YORK TIMES BESTSELLER • From the author of Timeline, Sphere, and Congo, this is the classic thriller of science run amok that took the world by storm. Nominated as one of America’s best-loved novels by PBS’s The Great American Read “[Michael] Crichton’s dinosaurs are genuinely frightening.”—Chicago Sun-Times An astonishing technique for recovering and cloning dinosaur DNA has been discovered. Now humankind’s most thrilling fantasies have come true. Creatures extinct for eons roam Jurassic Park with their awesome presence and profound mystery, and all the world can visit them—for a price. Until something goes wrong. . . . In Jurassic Park, Michael Crichton taps all his mesmerizing talent and scientific brilliance to create his most electrifying technothriller. Praise for Jurassic Park “Wonderful . . . powerful.”—The Washington Post Book World “Frighteningly real . . . compelling . . . It’ll keep you riveted.”—The Detroit News “Full of suspense.”—The New York Times Book Review

Gene Drives on the Horizon

Gene Drives on the Horizon Pdf/ePub eBook Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct
Editor: National Academies Press
ISBN: 0309437903
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Gene Drives on the Horizon by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct Summary

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

CRISPR-Cas Systems

CRISPR-Cas Systems Pdf/ePub eBook Author: Rodolphe Barrangou,John van der Oost
Editor: Springer Science & Business Media
ISBN: 364234657X
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CRISPR-Cas Systems by Rodolphe Barrangou,John van der Oost Summary

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

The Sneetches and Other Stories: Read & Listen Edition

The Sneetches and Other Stories: Read & Listen Edition Pdf/ePub eBook Author: Dr. Seuss
Editor: Random House Books for Young Readers
ISBN: 0385383126
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The Sneetches and Other Stories: Read & Listen Edition by Dr. Seuss Summary

Dr. Seuss creates another timeless picture-book classic with The Sneetches and Other Stories. Are you a Star-Belly Sneetch or a Plain-Belly Sneetch? This delightful book contains four tales with deliciously subtle takes on how silly it is to be, well, silly. “The Sneetches,” “The Zax,” “Too Many Daves,” and “What Was I Scared Of?” make this energetic compilation a must-have for every library. Full of Dr. Seuss’s signature rhymes and unmistakable characters, it’s perfect for new and lifelong Seuss fans. This Read & Listen edition contains audio narration.

Hacking Darwin

Hacking Darwin Pdf/ePub eBook Author: Jamie Metzl
Editor: Sourcebooks, Inc.
ISBN: 1492670103
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Hacking Darwin by Jamie Metzl Summary

"A gifted and thoughtful writer, Metzl brings us to the frontiers of biology and technology, and reveals a world full of promise and peril." — Siddhartha Mukherjee MD, New York Times bestselling author of The Emperor of All Maladies and The Gene Passionate, provocative, and highly illuminating, Hacking Darwin is the must read book about the future of our species for fans of Homo Deus and The Gene. After 3.8 billion years humankind is about to start evolving by new rules... From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic-engineering is shaking the core foundations of our lives — sex, war, love, and death. At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race. Enter the laboratories where scientists are turning science fiction into reality. Look towards a future where our deepest beliefs, morals, religions, and politics are challenged like never before and the very essence of what it means to be human is at play. When we can engineer our future children, massively extend our lifespans, build life from scratch, and recreate the plant and animal world, should we?

The Age of Surveillance Capitalism

The Age of Surveillance Capitalism Pdf/ePub eBook Author: Shoshana Zuboff
Editor: PublicAffairs
ISBN: 1610395700
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The Age of Surveillance Capitalism by Shoshana Zuboff Summary

The challenges to humanity posed by the digital future, the first detailed examination of the unprecedented form of power called "surveillance capitalism," and the quest by powerful corporations to predict and control our behavior. In this masterwork of original thinking and research, Shoshana Zuboff provides startling insights into the phenomenon that she has named surveillance capitalism. The stakes could not be higher: a global architecture of behavior modification threatens human nature in the twenty-first century just as industrial capitalism disfigured the natural world in the twentieth. Zuboff vividly brings to life the consequences as surveillance capitalism advances from Silicon Valley into every economic sector. Vast wealth and power are accumulated in ominous new "behavioral futures markets," where predictions about our behavior are bought and sold, and the production of goods and services is subordinated to a new "means of behavioral modification." The threat has shifted from a totalitarian Big Brother state to a ubiquitous digital architecture: a "Big Other" operating in the interests of surveillance capital. Here is the crucible of an unprecedented form of power marked by extreme concentrations of knowledge and free from democratic oversight. Zuboff's comprehensive and moving analysis lays bare the threats to twenty-first century society: a controlled "hive" of total connection that seduces with promises of total certainty for maximum profit -- at the expense of democracy, freedom, and our human future. With little resistance from law or society, surveillance capitalism is on the verge of dominating the social order and shaping the digital future -- if we let it.

Fables and Futures

Fables and Futures Pdf/ePub eBook Author: George Estreich
Editor: MIT Press
ISBN: 0262351803
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Fables and Futures by George Estreich Summary

How new biomedical technologies—from prenatal testing to gene-editing techniques—require us to imagine who counts as human and what it means to belong. From next-generation prenatal tests, to virtual children, to the genome-editing tool CRISPR-Cas9, new biotechnologies grant us unprecedented power to predict and shape future people. That power implies a question about belonging: which people, which variations, will we welcome? How will we square new biotech advances with the real but fragile gains for people with disabilities—especially when their voices are all but absent from the conversation? This book explores that conversation, the troubled territory where biotechnology and disability meet. In it, George Estreich—an award-winning poet and memoirist, and the father of a young woman with Down syndrome—delves into popular representations of cutting-edge biotech: websites advertising next-generation prenatal tests, feature articles on “three-parent IVF,” a scientist's memoir of constructing a semisynthetic cell, and more. As Estreich shows, each new application of biotechnology is accompanied by a persuasive story, one that minimizes downsides and promises enormous benefits. In this story, people with disabilities are both invisible and essential: a key promise of new technologies is that disability will be repaired or prevented. In chapters that blend personal narrative and scholarship, Estreich restores disability to our narratives of technology. He also considers broader themes: the place of people with disabilities in a world built for the able; the echoes of eugenic history in the genomic present; and the equation of intellect and human value. Examining the stories we tell ourselves, the fables already creating our futures, Estreich argues that, given biotech that can select and shape who we are, we need to imagine, as broadly as possible, what it means to belong.